Episode 15: Four Month Old Baby with Cancer in Both Eyes Benefits from Cannabis Oil



Listen to Liz from the United States (who does not want us to use her last name) whose baby was diagnosed with cancer in both eyes (retinal blastoma) at 4 …

17 Comments

  1. 17:38 = this is the mechanism = Role in hippocampal neurogenesis

    In the adult brain, the endocannabinoid system facilitates neurogenesis ("birth of new neurons") of hippocampal granule cells[32][33]. In the subgranular zone of the dentate gyrus, multipotent neural progenitors (NP) give rise to daughter cells that, over the course of several weeks, mature into granule cells whose axons project to and synapse onto dendrites on the CA3 region[34]. Very recent data suggests that the maturing granule cells are dependent on a reelin, a molecular guidance cue, for proper migration through the dentate gyrus (Gong et al., 2007). NPs in the hippocampus have been shown to possess FAAH and express CB1 and utilize 2-AG (Aguado et al., 2005). Intriguingly, CB1 activation by endogenous or exogenous promote NP proliferation and differentiation; this activation is absent in CB1 knockouts and abolished in the presence of antagonist (Aguada et al., 2005; Jiang et al., 2005).

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