21 Comments

  1. Hello Dr. My grandmother has pretty heavy essential tremors refuse to go to a doctor for treatment, she accepted to test canabis for treatment. I would like to have more information about canabioid dosage for essential tremors were could I reach you or someone qualified to help me with this goal. Thank you for your time

  2. i was 45, now 47, when i started to shake my head, i'm now at a point where my shoulders and upper back are starting to shake as well, and i cant stand it
    i have a couple of mental issues as well, a little bit of narcissism so this is not good for my self esteem, i avoid people
    also my dad had parkinsons at a very early age, i think he was ~40, i was 6 when he fell down went to a hospital and right after in a nursing home and he never returned, he was in there for 12 years, bedridden, till he died of pneumonia, so that plays a role in my head as well
    the last couple of months i've tried smoking cannabis and the shaking "calmed down" if its the result of less stress/anxiety i dont know
    tremor gives me stress and stress causes more tremors, so im stuck

    i havent tried cbd oil yet but seeing what it does to parkinsons patients i think i might try it
    if you have any ideas on how to calm it down, pls help, i really cant stand it
    i have had a brain scan, went to a neurologist, twice, but she couldnt see anything specific
    i know parkinsons usually starts with hands and shakes more while doing stuff and tremor the opposite, but its still in the back of my head
    oh, yeh, i have eye migraine as well, with auras, loads of em, sometimes 3-4 times a day for 3 days in a row, tho the last couple of months (with cannabis) they have appeared maybe 2 times, i get indications a day before the migraines, somber – down, colors more intense, light hurts my eyes but no auras or headaches with cannabis
    sorry for the wall of text 🙂

  3. Many years ago I was diagnosed with benign essential tremor. At the time the doctor told me that they were not having very good results with most of the treatments. He also told me that if it wasn’t bothering and if I could live with the shaking that it really wouldn’t do me any harm by not treating it and at the time it wasn’t so I elected to just accept the shaking and to move on with my life. Over the years, the tremors have gotten worse, at times I can’t even write my name and need 2 hands to drink a glass of water. The one thing that I have found that make my hand steady as a rock is alcohol but I also know that I can not treat my tremors that way.
    Now I am retired and most every hobby that I would like to pursue I can't are their a testing or trials that I would qualify for?

  4. Thank you Dr. Nahab for pursuing this clinical research. I have been self treating my own ET for 5 years with CBD infused oil, applied topically to the back of my neck at the hairline, and have seen consistent reduction of my ET. When I have a stressful event, I apply more and see calming in a few minutes. I can't wait for the results of your study, and encourage you to explore topical applications as well.

  5. I am a physical therapist with a loved one who has had his life taken over by essential tremor (ET). Lots of pertinent research to point to in past two decades to support conducting this study. Recent research has shown the following: (1) with essential tremor, cells in the cerebellum (Purkinje fibers) are structurally different and have altered connections with the cells they receive input from (climbing fibers and parallel fibers)–climbing fibers send motor messages to correct detected errors in movement and body position (resulting in helpful neurological adaptation, AKA plasticity, AKA motor learning) with an innate pacemaker motor signal frequency from the inferior olivary nucleus, and I would argue it is this pacemaker motor signal frequency (approx 1-10 Hz) that is ultimately abnormally relayed fwd by Purkinje fibers that results in an essential tremor that reflects this same pacemaker frequency (in other words, the cerebellum is sending fwd a signal for a movement or body position to be corrected when no correction is needed, and this displays itself as a tremor); (2) endocannabinoid receptors (especially CB1) are highly prevalent in the cerebellum and require endocannabinoid 2-AG to bind to them in order for appropriate message sending and neurological adaptation to occur–I would suggest that a lack of endocannabinoid 2-AG in the cerebellum does well to explain the structural changes of the cerebellum seen in ET; (3) THC from cannabis binds to CB1 receptors. If a lack of an endocannabinoid in the cerebellum is the problem in ET, and introducing the proper cannabinoid (THC) solves this problem, then I would hypothesize that not only would acute influence of THC on tremor be positive, but that regular ingestion of THC and keeping it in your system for a prolonged time to result in the appropriate neurological connections to repair back to normal (over time), literally undoing the brain changes that led to the ET condition in the first place. Also of note, recent research has demonstrated acute effects of alcohol to be inhibiting to climbing fiber message transmission to Purkinje fibers, meaning that alcohol inhibits the brains ability to send error information regarding movement and body position–I would argue this to explain why ET is acutely relieved by alcohol (no consistent message to correct movement or body position, no tremor).

  6. I’m really interested to see the results. I’m a 22 year old male and have had essential tremor for as long as I can remember and nothing gives me the mental clarity and symptom relief like weed. Small amounts of alcohol give me short-term relief but the rebound effect makes it not worth it.

  7. I’m all for research and development, however there seems to be a craze with cannabis/marijuana/THC. People claim it helps anxiety. There have been studies with people and their marijuana habit. THC has been found to cause anxiety and paranoia. The higher THC content, the worse the anxiety is. I myself have essential tremor. I’ve taken medication that helped tremendously and helped with my migraines. The side effects though were horrible. I’ve been looking into the trendy cbd oil and copaiba oil. I’ve found the type of cannabinoids in copaiba essential oil to help me. I do not have severe essential tremor but it is enough to affect my daily life. That’s my personal finding. Good luck in your research, I hope your studies lead to great discovery.

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